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. 2022 Jan 20;119(1):316–331. doi: 10.1093/cvr/cvac008

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© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Unilateral SCGx attenuates the ipsilateral CB-evoked sympathoexcitation (A and B), tachypnoea (D), and pressor responses (E) in SH rats (n = 10). (C) the CB-evoked bradycardia was unchanged. (A) Typical tracing of the tSNA (raw and integrated waveform) after chemoreflex stimulation. Sham (SCG) SH rats (n = 3) do not show a change in chemoreflex response over time. The chemoreflex was evoked with NaCN (0.4 µg/µL; 100 µL). Data were analysed using paired Student’s t-test to compare control vs. 10 min SCGx and a mixed-effects model from post 10 min SCGx onwards; *P < 0.05 vs. control and #P < 0.05 vs. 10 min ganglionectomy. Note: the reduced number of data points in (B–E) reflects the loss of high-quality recordings in two preparations.