Fig. 1. Graphical introduction to curvature sensing peptides.

(A) A peptide (in black) can have an enhanced affinity (thicker arrows) toward a curved or stretched membrane (in red) as opposed to a flat tensionless membrane (in orange), due to hydrophobic lipid packing defects between the lipid head groups. (B and C) Helical wheel representations (26) of ALPS1 from ArfGAP1 (8) and α-synuclein (9). Yellow, hydrophobic; gray, small; pink/purple, polar; blue, positively charged; red, negatively charged.