Skip to main content
. 2023 Mar 17;9(11):eadd3243. doi: 10.1126/sciadv.add3243

Fig. 1. HDAC3 is essential for lung tumorigenesis in vivo in KL and KP GEMM models of NSCLC.

Fig. 1.

(A) Schematic of experimental design in KrasG12D/+, LKB1L/L (KL), and KL-HDAC3L/L (KL-HDAC3) mouse models administered lentivirus expressing Cre recombinase (Lenti-Cre). (B) Representative hematoxylin and eosin (H&E)–stained sections from the late time point. Scale bar, 1000 μm. (C) Quantitation from H&E-stained sections from the late time point cohort: Tumor area as a percentage of total lung area per mouse (n = 10), tumor number per mouse (n = 10), and average tumor size (n = 482 or 230 as indicated). (D) Schematic of experimental design in KrasG12D/+, p53L/L (KP), and KP-HDAC3L/L (KP-HDAC3) mouse models administered Lenti-Cre. (E) Representative H&E-stained sections. Scale bar, 1000 μm. (F) Quantitation from H&E-stained sections: tumor area as a percentage of total lung area per mouse (n = 9 or 6 as indicated), tumor number per mouse (n = 9 or 6 as indicated), and average tumor size (n = 115 or 33 as indicated). Values are expressed as means ± SEM. *P < 0.05 and ****P < 0.0001, determined by two-tailed Mann-Whitney test.