Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Mar 17;9(11):eade4395. doi: 10.1126/sciadv.ade4395

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Fig. 3. — (A) Cryo-EM density map of the CRLF1-CLCF1-CNTFRα complex. The two sets of molecules in the hexameric complex are annotated as CRLF1, CLCF1, CNTFRα, CRLF1′, CLCF1′, and CNTFRα′. (B) Cartoon representation of the CRLF1-CLCF1-CNTFRα complex. Site 2 and site 3 interfaces and the CRLF1 dimer interface with corresponding buried surface areas calculated by PDBePISA are indicated by arrows. (C to E) Details of binding interfaces at site 2 (C), site 3 (D), and the CRLF1 dimer interface (E), as indicated in (B). (F and G) Histograms of buried surface area for CLCF1 residues at site 2/2a (F) and site 3 (G) interfaces in the LIFR-gp130-CLCF1-CNTFRα complex (CLCF1 signaling complex) and the CRLF1-CLCF1-CNTFRα complex.