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. 2023 Mar 17;9(11):eade4582. doi: 10.1126/sciadv.ade4582

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Fig. 5. — (A) Scatterplot showing log₂ fold change of PB-HGD versus PB-LGD (x axis) and INT-HGD versus INT-LGD (y axis). Significant DE genes are colored by histopathologic subgroup. Top 10 DE genes from each analysis are labeled. (B) Boxplots showing the log-normalized gene expression of histopathologic marker genes. (C) Barplots depicting GSEA normalized enrichment score obtained from testing of histopathologic groups against several external PDAC gene sets. Bar colors depict the P_adj of each test. Gray bars are not statistically significant (P_adj > 0.05). (D) Volcano plots of MSigDB Hallmark gene sets associated with each histopathologic subgroup (relative to its counterparts), with statistical significance plotted on the x axis and normalized enrichment score plotted on the y axis. Significant enrichment results (P_adj < 0.01) are shown with text labels.