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The anti-SARS-CoV-2 properties of Galidesivir against different cell cultures.
| Cell line | SARS-CoV-2 strains | Assay | Incubation period | EC50 (μM) | EC90 (μM) | CC50 (μM) | SI |
|---|---|---|---|---|---|---|---|
| Caco-2 | WA1/2020 | VYRa | 24 h | n.d.b | 14.19 | 82.8 | 5.8 |
| Vero-76 | WA1/2020 | VYRa | 24 h | n.d.b | 10.94 | >295.7 | >27 |
| CPEc | 50.3 | 5.8 | |||||
| Calu-3 | WA1/2020 | Imaging | 2 h | 14.15 | n.d. | >50 | >3.5 |
VYR = Viral Yield Reduction.
n.d. = not determined.
CPE = cytopathic effect.
