Table 2.

Associations of total percent lean mass loss and total percent fat mass gain during the menopause transition (MT) with bone mineral density (BMD) level at the end of the MT ¹

	Associations per standard deviation (SD) lean mass loss or SD fat mass gain during the MT with BMD at the end of the MT 2,3,4
	Femoral neck (FN) BMD (g/cm2)		Lumbar spine (LS) BMD (g/cm2)
	Beta (95% CI)	p-value	Beta (95% CI)	p-value
Cumulative lean mass loss (per SD)	−0.010 (−0.013, −0.006)	<0.0001	−0.004 (0.009, 0.000)	0.09
Cumulative fat mass gain (per SD)	0.026 (0.007, 0.045)	0.009	0.026 (0.002, 0.050)	0.03

^1.Associations estimated using multivariable linear regression with FN or LS BMD after the MT as outcome, and cumulative % loss in lean mass and gain in fat mass (tested together) as primary predictors, controlled for lean mass level (kg) and fat mass level (kg) at the start of the MT. Other model covariates were race/ethnicity, study site, age, cigarette use, FN or LS BMD at start of the MT, and use of bone detrimental medications during the MT.

^2.Mean and SD of cumulative percent lean mass loss during the MT = 0.7% (6.9%)

^3.Mean and SD of cumulative percent fat mass gain during the MT = 6.0% (19.9%)

^4.Beta coefficients represent the decrement or increment in BMD level per 1 SD increment in exposure.