TABLE 3.

Clinical trials on nonviral nanoparticles for gene delivery to the brain

Name	Indication	Therapeutic molecule	Type of nanocarrier	Clinical trial
Nusinersen	Spinal muscular atrophy	Antisense oligonucleotide targeting ISS-N1	Antisense oligonucleotide	NCT04591678
NU-0129	Glioblastoma	siRNAs targeting Bcl2L12, a glioblastoma oncogene	Gold nanoparticles	NCT03020017
BIIB094	Parkinson’s disease	Antisense oligonucleotide targeting LRRK2	Antisense oligonucleotide	NCT03976349
ALN-APP	Alzheimer’s disease; cerebral amyloid angiopathy	RNAi targeting amyloid precursor protein (APP)	RNA interference	NCT05231785