Table 1.
Baseline Characteristics of IL-1β Participants By Weighted1 Tertile of IL-1β
| Tertile 1 (n=1261) |
Tertile 2 (n=746) |
Tertile 3 (n=1004) |
|||||
|---|---|---|---|---|---|---|---|
| N | % | N | % | N | % | p-value | |
| Demographics | |||||||
| Age, mean (SD) | 65.6 | (6.9) | 63.5 | (6.5) | 64.2 | (6.9) | <0.001 |
| Race | |||||||
| American Indian / Alaska Native | 11 | 0.9 | 6 | 0.8 | 13 | 1.3 | |
| Asian | 69 | 5.5 | 26 | 3.5 | 28 | 2.8 | |
| Native Hawaiian / Pacific Islander | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | |
| Black / African American | 192 | 15.2 | 209 | 28.0 | 260 | 25.9 | |
| White | 933 | 74.0 | 489 | 65.5 | 662 | 65.9 | |
| More than one race | 18 | 1.4 | 6 | 0.8 | 18 | 1.8 | |
| Unknown / not reported | 38 | 3.0 | 10 | 1.3 | 23 | 2.3 | |
| Ethnicity | 0.01 | ||||||
| Hispanic / Latina | 95 | 7.5 | 27 | 3.6 | 45 | 4.5 | |
| Not Hispanic / Latina | 1151 | 91.3 | 709 | 95.0 | 948 | 94.4 | |
| Unknown / not reported | 15 | 1.2 | 10 | 1.3 | 11 | 1.1 | |
| Income | 0.42 | ||||||
| <$20,000 | 255 | 20.2 | 132 | 17.7 | 171 | 17.0 | |
| $20,000-$49,999 | 526 | 41.7 | 316 | 42.4 | 431 | 42.9 | |
| $50,000-$74,999 | 213 | 16.9 | 130 | 17.4 | 179 | 17.8 | |
| ≥$75,000 | 176 | 14.0 | 127 | 17.0 | 150 | 14.9 | |
| Education | 0.06 | ||||||
| ≤High school/GED | 318 | 25.2 | 157 | 21.0 | 218 | 21.7 | |
| Some college | 486 | 38.5 | 261 | 35.0 | 380 | 37.8 | |
| College degree or higher | 457 | 36.2 | 328 | 44.0 | 406 | 40.4 | |
| Medical History | |||||||
| BMI, mean (SD) | 28.1 | (6.1) | 27.7 | (5.9) | 27.8 | (5.9) | 0.31 |
| Hypertension | |||||||
| Never treated | 656 | 52.0 | 548 | 73.5 | 650 | 64.7 | <0.001 |
| Currently untreated | 230 | 18.2 | 69 | 9.2 | 132 | 13.1 | |
| Treated | 375 | 29.7 | 129 | 17.3 | 222 | 22.1 | |
| Diabetes mellitus | 61 | 4.8 | 40 | 5.4 | 63 | 6.3 | 0.14 |
| Hyperlipidemia | 192 | 15.2 | 96 | 12.9 | 139 | 13.8 | 0.36 |
| Coronary artery disease | 43 | 3.4 | 13 | 1.7 | 14 | 1.4 | 0.002 |
| MI | 27 | 2.1 | 11 | 1.5 | 12 | 1.2 | 0.09 |
| CABG/PTCA | 27 | 2.1 | 9 | 1.2 | 10 | 1.0 | 0.03 |
| Stroke | 16 | 1.3 | 5 | 0.7 | 5 | 0.5 | 0.09 |
| Heart failure | 13 | 1.0 | 2 | 0.3 | 7 | 0.7 | 0.40 |
| Peripheral arterial disease | 37 | 2.9 | 10 | 1.3 | 13 | 1.3 | 0.008 |
| Systolic BP, mean (SD) | 128.7 | (17.5) | 124.4 | (17.2) | 125.4 | (16.4) | <0.001 |
| Diastolic BP, mean (SD) | 74.0 | (9.6) | 74.0 | (8.5) | 73.8 | (8.6) | 0.60 |
| Heart rate, mean (SD) | 69.6 | (11.1) | 69.0 | (11.5) | 70.2 | (12.3) | 0.21 |
| Habits | |||||||
| Smoking status | |||||||
| Never | 668 | 53.0 | 394 | 52.8 | 494 | 49.2 | 0.20 |
| Past | 498 | 39.5 | 304 | 40.8 | 431 | 42.9 | |
| Current | 95 | 7.5 | 48 | 6.4 | 79 | 7.9 | |
| Alcohol | |||||||
| Never | 182 | 14.4 | 98 | 13.1 | 139 | 13.8 | 0.85 |
| Past | 308 | 24.4 | 161 | 21.6 | 240 | 23.9 | |
| Current | 762 | 60.4 | 482 | 64.6 | 620 | 61.8 | |
1
Tertiles defined by distribution of IL-1B inverse probability weighted to the WHI observational study
2
p-value compares Tertile 1 vs. Tertile 3 using t-tests for continuous markers and chi-square tests for categorical markers
All values represent the total and percentage of participants unless otherwise indicated.
BMI, body mass index; GED, general educational development; MI, myocardial infarction; CABG, coronary artery bypass graft; PTCA, percutaneous transluminal coronary angioplasty.