Table 2.
Multivariate-adjusted Hazard Ratios of Incident Atrial Fibrillation
| Age / Race Adjusted | Multivariate Adjusted1 Including BMI |
Multivariate Adjusted1 Excluding BMI |
||||
|---|---|---|---|---|---|---|
| Characteristic | HR (95% CI) | P-Value | HR (95% CI) | P-Value | HR (95% CI) | P-Value |
| BMI (5 kg/m2 increase) | 1.15 (1.11, 1.19) | <0.001 | 1.11 (1.07, 1.15) | <0.001 | ||
| IL-1B, pg/mL | 0.98 | 0.98 | 0.98 | |||
| Tertile 1 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |||
| Tertile 2 | 0.98 (0.74, 1.29) | 0.98 (0.73, 1.30) | 0.97 (0.73, 1.29) | |||
| Tertile 3 | 1.01 (0.78, 1.31) | 1.00 (0.77, 1.30) | 1.00 (0.77, 1.30) | |||
| Linear Trend | 1.01 (0.88, 1.14) | 0.94 | 1.00 (0.88, 1.14) | >0.99 | 1.00 (0.87, 1.14) | 0.99 |
| Continuous Log | 0.89 (0.70, 1.13) | 0.32 | 0.86 (0.66, 1.11) | 0.24 | 0.85 (0.66, 1.10) | 0.23 |
| IL-7, pg/mL | 0.35 | 0.22 | 0.24 | |||
| Tertile 1 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |||
| Tertile 2 | 0.85 (0.48, 1.53) | 0.74 (0.41,1.35) | 0.76 (0.42, 1.36) | |||
| Tertile 3 | 1.27 (0.65, 2.46) | 1.22 (0.66, 2.24) | 1.21 (0.66, 2.24) | |||
| Linear Trend | 1.14 (0.79, 1.63) | 0.49 | 1.12 (0.80, 1.58) | 0.51 | 1.12 (0.79, 1.58) | 0.52 |
| Continuous Log | 1.07 (0.66, 1.71) | 0.79 | 1.04 (0.67, 1.61) | 0.87 | 1.03 (0.67, 1.61) | 0.88 |
| IL-8, pg/mL | 0.91 | 0.98 | 0.98 | |||
| Tertile 1 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |||
| Tertile 2 | 0.89 (0.51, 1.53) | 0.95 (0.56, 1.63) | 0.95 (0.56, 1.63) | |||
| Tertile 3 | 0.92 (0.48, 1.78) | 0.98 (0.53, 1.84) | 0.98 (0.52, 1.84) | |||
| Linear Trend | 0.96 (0.68, 1.34) | 0.80 | 0.99 (0.72, 1.36) | 0.95 | 0.99 (0.72, 1.36) | 0.95 |
| Continuous Log | 0.97 (0.49, 1.92) | 0.92 | 1.06 (0.57, 1.97) | 0.87 | 1.05 (0.56, 1.97) | 0.87 |
| IL-10, pg/mL | 0.61 | 0.50 | 0.50 | |||
| Tertile 1 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |||
| Tertile 2 | 0.89 (0.65, 1.21) | 0.85 (0.62, 1.16) | 0.85 (0.62, 1.16) | |||
| Tertile 3 | 1.02 (0.74, 1.41) | 0.98 (0.71, 1.37) | 0.98 (0.71, 1.37) | |||
| Linear Trend | 1.01 (0.85, 1.19) | 0.92 | 0.99 (0.84, 1.18) | 0.93 | 0.99 (0.84, 1.18) | 0.93 |
| Continuous Log | 1.07 (0.91, 1.27) | 0.41 | 1.05 (0.88, 1.25) | 0.56 | 1.05 (0.88, 1.25) | 0.57 |
| IGF-1, ng/mL | 0.61 | 0.61 | 0.64 | |||
| Tertile 1 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |||
| Tertile 2 | 1.06 (0.80, 1.42) | 1.06 (0.80, 1.42) | 1.06 (0.79, 1.42) | |||
| Tertile 3 | 1.15 (0.87, 1.51) | 1.15 (0.87, 1.51) | 1.14 (0.87, 1.50) | |||
| Linear Trend | 1.07 (0.93, 1.23) | 0.32 | 1.07 (0.93, 1.23) | 0.32 | 1.07 (0.93, 1.22) | 0.35 |
| Continuous Log | 1.29 (0.91, 1.85) | 0.16 | 1.33 (0.93, 1.89) | 0.11 | 1.31 (0.92, 1.87) | 0.14 |
| TNF-alpha, pg/mL | 0.05 | 0.13 | 0.13 | |||
| Tertile 1 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |||
| Tertile 2 | 1.29 (1.05, 1.58) | 1.23 (1.01, 1.51) | 1.23 (1.01, 1.51) | |||
| Tertile 3 | 1.16 (0.96, 1.41) | 1.10 (0.91, 1.34) | 1.12 (0.92, 1.37) | |||
| Linear Trend | 1.07 (0.98, 1.17) | 0.15 | 1.05 (0.95, 1.15) | 0.36 | 1.05 (0.96, 1.16) | 0.27 |
| Continuous Log | 1.02 (0.92, 1.12) | 0.77 | 0.99 (0.89, 1.10) | 0.87 | 1.00 (0.90, 1.11) | 0.99 |
| CRP, mg/L | <0.001 | <0.001 | <0.001 | |||
| Tertile 1 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |||
| Tertile 2 | 1.10 (0.99, 1.22) | 1.01 (0.91, 1.13) | 1.05 (0.94, 1.17) | |||
| Tertile 3 | 1.47 (1.32, 1.63) | 1.25 (1.12, 1.39) | 1.33 (1.19, 1.47) | |||
| Linear Trend | 1.22 (1.15, 1.28) | <0.001 | 1.12 (1.06, 1.19) | <0.001 | 1.16 (1.10, 1.22) | <0.001 |
| Continuous Log | 1.17 (1.12, 1.22) | <0.001 | 1.09 (1.04, 1.14) | <0.001 | 1.12 (1.07, 1.17) | <0.001 |
| IL-6, pg/mL | <0.001 | 0.004 | <0.001 | |||
| Tertile 1 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |||
| Tertile 2 | 1.08 (0.95, 1.23) | 1.02 (0.89, 1.17) | 1.05 (0.92, 1.19) | |||
| Tertile 3 | 1.36 (1.20, 1.53) | 1.21 (1.06, 1.37) | 1.27 (1.12, 1.44) | |||
| Linear Trend | 1.17 (1.10, 1.25) | <0.001 | 1.10 (1.04, 1.18) | 0.003 | 1.13 (1.06, 1.21) | <0.001 |
| Continuous Log | 1.22 (1.14, 1.31) | <0.001 | 1.16 (1.08, 1.24) | <0.001 | 1.18 (1.11, 1.27) | <0.001 |
1
Multivariate models are adjusted for age, race/ethnicity (Black, White, Hispanic, Other/Not Reported), education, hypertension, diabetes, hyperlipidemia, hx of CHD (MI/CABG/PTCA), hx of ChF, hx of PAD, current smoking, BMI.
BMI, body mass index; GED, general educational development; MI, myocardial infarction; CABG, coronary artery bypass graft; PTCA, percutaneous transluminal coronary angioplasty.
All models are weighted to the WHI OS using IPW weighting