Several approaches can be used to mildly elevate the plasma bilirubin level above the optimal threshold. These include (i) Lifestyle approach (proper body composition, modest calorie restriction with a healthy diet rich in carbohydrates, fruit and vegetables, and sufficient aerobic activities); (ii) Nutraceutical approach, and finally; (iii) Pharmacological approach including nutraceuticals and drugs modulating HMOX/UGT1A1 activities as well as hepatic bilirubin transporting functions.
This figure was created by Matthew Hazzard at the University of Kentucky College of Medicine.