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. Author manuscript; available in PMC: 2024 Mar 15.
Published in final edited form as: Neuron. 2023 Jan 9;111(6):807–823.e7. doi: 10.1016/j.neuron.2022.12.014

Fig.2. Anti-epileptic efficacy and safety of chemically matured cINs.

Fig.2.

(A) Typical seizure EEG activity.

(B) Seizure frequency and duration in the PILO-TLE group vs the PILO-TLE + cIN group at four-month post-transplant.

(C) Open zone times and total distances between the PILO-TLE group vs the PILO-TLE + cIN group in EPM test at five months post-transplant.

(D) Seizure frequency and duration in the PILO-TLE group vs the PILO-TLE + cIN group at nine months post-transplant.

(E) Immunostaining and cell counting analysis of KI67 and SOX6 expression on grafted cINs at nine months post-transplant as analyzed from every 12th 40μm coronal brain section from four grafted mice per group.

(F) Abnormalities of inhibitory synapse densities and excitatory synapse densities in the dentate gyrus of PILO-TLE mice was restored by cIN transplantation.

Error bars are the SEM.