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. Author manuscript; available in PMC: 2024 Mar 15.
Published in final edited form as: Neuron. 2023 Jan 9;111(6):807–823.e7. doi: 10.1016/j.neuron.2022.12.014

Fig. 5. Chemically matured human cIN grafts restore comorbid behavioral deficits.

Fig. 5.

(A) EPM analysis of human cIN-grafted KA-TLE mice. Upper panel: representative heat map image. Lower panel: time spent in open arms by naïve, KA-TLE and KA-TLE + cIN groups at three months and nine months post-transplant.

(B) Sucrose preference test in naïve, KA-TLE and KA-TLE + cIN groups at three months and nine months post-transplant.

(C) Social interaction test. Upper panel: representative heat map image. Lower panel: Social interaction index in naïve, KA-TLE and KA-TLE + cIN groups at three months and nine months post-transplant.

(D) Y-maze analysis. Upper panel: representative heat map image. Lower panel: % of alteration of naïve, KA-TLE and KA-TLE + cIN groups at three months and nine months post-transplant.

(E) Novel object recognition test. Upper panel: representative heat map image. Lower panel: discrimination index of naïve, KA-TLE and KA-TLE + cIN groups at three months post-transplant and nine months post-transplant.

Heat map indicates total duration of stay (in seconds) in a given spot. Error bars are the SEM. See also Fig S9.