Table 3:
Clinical Outcome of Patients with Streptococcal Infection, Stratified by Treatment with IV Only versus PO Stepdown Antibiotics.
| Variable1 | Overall (n=244) |
IV only (n=153) |
PO stepdown (n=111) |
P value |
|---|---|---|---|---|
| Primary outcome | ||||
| Clinical failure 2 | 57 (21.6) | 37 (24.2) | 20 (18.0) | 0.233 |
| 90-day mortality | 7/262 (2.7) | 4/152 (2.6) | 3/110 (2.7) | 1.003 |
| Readmission within 90 days | 53 (20.1) | 35 (22.9) | 18 (16.2) | 0.183 |
| Readmission due to recurrent strep bacteremia | 6/53 (11.3) | 5/35 (14.3) | 1/18 (5.6) | 0.653 |
| Secondary outcomes | ||||
| Length of stay (days) | 5 (4-9) | 7 (5-13.5) | 4 (3-5) | < 0.0014 |
| Discharge home | 192 (72.7) | 98 (64.1) | 94 (84.7) | 0.0013,5 |
| Antibiotic-associated adverse events 6 | 4 (1.5) | 2 (1.3) | 2 (1.8) | 0.743 |
Abbreviations: IV, intravenous; N, number of patients; PO, per os
1
Data presented as n (%) or as median (interquartile range).
2
Composite of 90-day mortality and/or 90-day readmission
3
Chi square test with continuity correction,
4
Mann Whitney U test
5
Comparison used between home versus skilled nursing plus rehabilitation facility, plus self-directed discharge,
6
Types of antibiotic associated with adverse events included Clostridium difficile infection (n=2), leukopenia (n=1), and skin rash (n=1).