Table 2.
T3SS-Dependent Effectors in the Typhi Ty2 Genome
| Effector | Ty2 Locus | CT18 Locus | STm LT2 Locus | Paratyphi A 9150 Locus |
Locus Location |
T3SS-1 | T3SS- 2 |
|---|---|---|---|---|---|---|---|
| AvrA | ⊘ | ⊘ | STM2865 | ⊘ | SPI-1 | ✔ | ✔ |
| GogB | ⊘ | ⊘ | STM2584 | ⊘ | Gifsy-1 | ✔ | ✔ |
| GtgA | ⊘ | ⊘ | STM1026 | ⊘ | Gifsy-2 | ✔ | ✔ |
| GtgE | ⊘ | ⊘ | STM1055 | ⊘ | Gifsy-2 | ✔ | ✔ |
| PipB2 | T_RS13590 | STY2897 | STM2780 | SPA_RS13395 | ST27 | ✔ | ✔ |
| SlrP | T_RS10620 | STY0833 | STM0800 | SPA_RS09800 | - | ✔ | ✔ |
| SpvC | ⊘ | ⊘ | PSLT038 | ⊘ | pSLT | ✔ | ✔ |
| SpvD | ⊘ | ⊘ | PSLT037 | ⊘ | pSLT | ✔ | ✔ |
| SspH1 | ⊘ | ⊘ | STM14_RS07010 | ⊘ | Gifsy-3 | ✔ | ✔ |
| SteA | T_RS07605 | STY1482 | STM1583 | SPA_RS06440 | - | ✔ | ✔ |
| SteB | ⊘ | ⊘ | STM1629 | ⊘ | - | ✔ | ✔ |
| SteE (SarA) | ⊘ | ⊘ | STM2585 | ⊘ | Gifsy-1 | ✔ | ✔ |
| SipA | T_RS14125 | STY3005 | STM2882 | SPA_RS13925 | SPI-1 | ✔ | |
| SipB | T_RS14140 | STY3008 | STM2885 | SPA_RS13940 | SPI-1 | ✔ | |
| SipC | T_RS14135 | STY3007 | STM2884 | SPA_RS13935 | SPI-1 | ✔ | |
| SipD | T_RS14130 | STY3006 | STM2883 | SPA_RS13930 | SPI-1 | ✔ | |
| SopA | T_RS04065 | STY2275 | STM2066 | SPA_RS04025 | - | ✔ | |
| SopB | T_RS09305 | STY1121 | STM1091 | SPA_RS08830 | SPI-5 | ✔ | |
| SopD | T_RS14435 | STY3073 | STM2945 | SPA_RS14235 | - | ✔ | |
| SopE | T_RS21905 | STY4609 | SL1344_RS13925 | SPA_RS12970 | SopEφ | ✔ | |
| SopE2 | T_RS05225 | STY1987 | STM1855 | SPA_RS05115 | - | ✔ | |
| SopF | T_RS05655 | STY1893 | STM1239 | SPA_RS08080 | SPI-11 | ✔ | |
| SptP* | T_RS14105 | STY3001 | STM2878 | SPA_RS13905 | SPI-1 | ✔ | |
| StoD | T_RS09505 | STY1076 | ⊘ | ⊘ | ST10 | ✔ | |
| GogA | ⊘ | ⊘ | STM2614 | ⊘ | Gifsy-1 | ✔ | |
| CigR | T_RS19110 | STY4024 | STM3762 | SPA_RS18310 | SPI-3 | ✔ | |
| PipA | T_RS09330 | STY1115 | STM1087 | SPA_RS08855 | SPI-5 | ✔ | |
| PipB | T_RS09325 | STY1117 | STM1088 | SPA_RS08850 | SPI-5 | ✔ | |
| SifA | T_RS08635 | STY1264 | STM1224 | SPA_RS08155 | - | ✔ | |
| SifB | T_RS07700 | STY1462 | STM1602 | SPA_RS06345 | - | ✔ | |
| SopD2 | T_RS09990 | STY0971 | STM0972 | SPA_RS09170 | - | ✔ | |
| SpiC | T_RS06440 | STY1727 | SL1344_RS06920 | SPA_RS07330 | SPI-2 | ✔ | |
| SpvB | ⊘ | ⊘ | PSLT039 | ⊘ | pSLT | ✔ | |
| SrfA | T_RS07655 | STY1472 | STM1593 | SPA_RS06390 | - | Pred. | |
| SrfB | T_RS07660 | STY1471 | STM1594 | SPA_RS06385 | - | Pred. | |
| SrfC | T_RS07665 | STY1470 | STM1595 | SPA_RS06380 | - | Pred. | |
| SrfJ | ⊘ | ⊘ | STM4426 | ⊘ | - | ✔ | |
| SseB | T_RS06465 | STY1722 | STM1398 | SPA_RS07305 | SPI-2 | ✔ | |
| SseC | T_RS06475 | STY1720 | STM1400 | SPA_RS07295 | SPI-2 | ✔ | |
| SseD | T_RS06480 | STY1719 | STM1401 | SPA_RS07290 | SPI-2 | ✔ | |
| SseF | T_RS06495 | STY1716 | STM1404 | SPA_RS07275 | SPI-2 | ✔ | |
| SseG | T_RS06500 | STY1715 | STM1405 | SPA_RS07270 | SPI-2 | ✔ | |
| SseI (srfH) | ⊘ | ⊘ | STM1051 | ⊘ | Gifsy-2 | ✔ | |
| SseJ | T_RS25885 | STY_RS06750 | STM1631 | ⊘ | - | ✔ | |
| SseK1 | ⊘ | ⊘ | STM4157 | ⊘ | - | ✔ | |
| SseK2 | T_RS23900 | STY_RS11125 | SL1344_RS10980 | SPA_RS23070 | - | ✔ | |
| SseK3 | ⊘ | ⊘ | SL1344_RS10000 | ⊘ | ST64B | ✔ | |
| SseL | T_RS02915 | STY2517 | SL1344_RS11745 | SPA_RS02885 | - | ✔ | |
| SspH2 | T_RS03160 | STY2467 | STM2241 | ⊘ | SPI-12 | ✔ | |
| SteC | T_RS08195 | STY1353 | STM1698 | SPA_RS05905 | - | ✔ | |
| SteD | T_RS03630 | STY2367 | STM2139 | SPA_RS03565 | - | ✔ |
Grey box = Gene has a frameshift or early truncation in S. Typhi relative to S. Typhimurium, assumed to be non-functional
*
= The sptP gene is mutated and non-functional in S. Typhi
⊘ = Gene is absent from this serovar
✔ = S. Typhimurium translocation of this effector is dependent on T3SS-1, −2 or both. “Pred.” means predicted but not yet directly demonstrated.
If there is no homolog in S. Typhimurium str. LT2, homolog in strain SL1344 or 14028 given instead.