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. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: Brain Behav Immun. 2023 Jan 19;109:204–218. doi: 10.1016/j.bbi.2023.01.009

Figure 7. Treadmill exercise stimulates the recruitment of PPARα to the ADAM10 gene promoter in vivo in the hippocampus of Tg mice.

Figure 7.

The schematic diagram shows the presence of PPRE in the ADAM10 promoter very close (−7 bp to −30 bp) to the transcription start site (A). Genomic DNA was isolated from hippocampal tissues of normal as well as treadmill-exercised non-Tg (B & C) and Tg (D & E) mice and binding of PPARα, PPARβ, PPARγ, CBP, and RNA polymerase to the PPRE site was analyzed by chromatin immunoprecipitation (ChIP) followed by semi-quantitative (B & D) and real-time PCR (C & E) quantification of the PPRE-containing 205 bp fragment. Results are mean ± SEM of four mice per group. ***p< 0.001.