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. Author manuscript; available in PMC: 2024 Apr 1.
Published in final edited form as: Curr Opin Virol. 2023 Mar 2;59:101305. doi: 10.1016/j.coviro.2023.101305

Figure 5. Structure of NS5 MTase-RdRp and its inhibitors.

Figure 5.

(A) Overall structure of DENV3 full length NS5. MTase domain is colored in yellow. Fingers Palm and Thumb domains of the RdRp are colored in green, cyan, and pink. Linker region is colored in orange. (B) View of the RdRp active site, marked with a triangle. The allosteric inhibitors binds a novel pocket on the Thumb domain next to the active site. Chemical structure of the (C) Compound 29 [114], (D) NITD008. (E) AT-752.