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. Author manuscript; available in PMC: 2024 Mar 17.
Published in final edited form as: Circ Res. 2023 Feb 17;132(6):723–740. doi: 10.1161/CIRCRESAHA.122.321604

Figure 5. Systemic Hypoxemia stimulates cardiac remodeling with fibrosis and non-myocyte cell proliferation.

Figure 5.

Adult hearts were stained for CD31 (red, labels endothelial cells), EdU (green), and DAPI (blue). A: Capillary density and size was measured in LV and RV sections of the heart. B: Total CD31+ cells and total EdU+ CD31+ cells were quantified. C: Fibrosis was analyzed and quantified by Picro Sirius Red staining and gene expression level of collagen 3a1 (col3a1), collagen 1a1 (col1a1), and Periostin (Postn) by RT-PCR. D: Heart sections were stained for αSA (red, labels cardiomyocytes), TUNEL (green, apoptotic cells), and DAPI (blue, nuclei) to label total apoptotic (TUNEL+) cells (n=4-5 mice). Data represented as mean±SD.