Fig. 3. Proviral diversity is low in productively infected cells during acute HIV infection.
A. Phylogenetic trees representing HIV C2-V5 env proviral sequences obtained from single-sorted p24+ cells from n=7 participants (PID#18 to #25). Trees were rooted on a CRF01_AE consensus (grey square) and env sequences from each single p24+ cell are depicted in red or blue according to their compartments (blood or lymph node, respectively). Identical sequences are shown as aggregated on the same branch of the tree. B. Pie charts representing the relative proportion of each C2V5 env sequence for each participant in both blood and lymph node. The number of p24+ cells analyzed is indicated in the center of the pie. Identical sequences are depicted in colors, whereas unique sequences are depicted in grey.