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. Author manuscript; available in PMC: 2024 May 1.
Published in final edited form as: Semin Cancer Biol. 2023 Feb 15;90:29–44. doi: 10.1016/j.semcancer.2023.02.003

Figure 1. Transcription factors mediate cancer cell lineage plasticity, which enables the phenotypic switch of cancer cells and drives metastasis, stemness and drug resistance.

Figure 1

Resistant cancer cells surviving from anti-cancer treatment can undergo further transformation and leverage these malignant properties to promote cancer metastasis. TFs: transcription factors.