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. Author manuscript; available in PMC: 2024 May 1.
Published in final edited form as: Semin Cancer Biol. 2023 Feb 15;90:29–44. doi: 10.1016/j.semcancer.2023.02.003

Table 2.

Drugs targeting KLF4 and KLF5

Mechanism Compounds
KLF4 Inhibit KLF4 transcription Kenpaullone [128]
Regorafenib [273]
Enhance KLF4 transcription PKA inhibitors: H89 and 14–22 Amide (PKI) [128,198]
APTO-253 [262]
Reduce KLF4 protein Simvastatin and atorvastatin [178]
KLF5 Inhibit KLF5 transcription Wortmannin (a PI3K/AKT inhibitor), AG17, and AG879 [263]
Inhibit KLF5 expression via inducing miRNA targeting KLF5 Mifepristone [222]
Crocin [227]
Promotes KLF5 proteasome degradation Curcumin [265]
Metformin [155]