Table 1.

Summary of the main focus of previous review articles on nitrosamine contamination.

Year of Publication	Title	Main focus	Ref.
2019	Short commentary on NDMA (N-nitrosodimethylamine) contamination of valsartan products	Specific review of NDMA contamination in valsartan products	Snodin and Elder (2019)
2020	Nitrosamine impurities in drug substances and drug products	Review of nitrosamine cross-contamination possibilities to pharmaceuticals, limits and acceptable intake of NDMA and NDEA in sartans and published analytical techniques.	Shaikh et al. (2020)
2020	Regulatory updates and analytical methodologies for nitrosamine impurities detection in sartans, ranitidine, nizatidine, and metformin along with sample preparation techniques	Basic principles and recently updated information on methods and sample preparation for nitrosamine analysis.	Shaik et al. (2020)
2020	Pathways for N-nitroso compound formation: Secondary amines and beyond	The reaction conditions and reactant leading to N-nitroso compound formations.	López-Rodriguez et al. (2020)
2021	Nitrosamine contamination in pharmaceuticals: Threat, Impact, and Control	The source of nitrosamine contamination in pharmaceuticals such as sartans, ranitidine and nizatidine. Discuss the methodologies for trace nitrosamine analyses, risk assessment-based approach and control measures.	Tuesuwan and Vongsutilers (2021)
2021	N-nitrosodimethylamine (NDMA) contamination of Ranitidine Products: A review of recent findings	Specific observation of ranitidine degradation to NDMA	Aldawsari et al. (2021)
2021	Presence of nitrosamine impurities in medicinal products	Short communication of the EU regulatory response and the Croatian market situation on NDMA and NDEA contamination events in pharmaceutical products	Sedlo et al. (2021)
2021	Critical analysis of drug product recalls due to nitrosamine impurities.	Case reports and risk analysis of drug product recalls due to the nitrosamine impurities	Bharate (2021)
2021	An organic chemist’s guide to N-nitrosamines: Their structure, reactivity, and role as contaminants	The perspective on the chemical structure, reactivity, and synthetic applications of alkyl N-nitrosamines	Beard and Swager (2021)
2021	Nitrosamine reactivity: A survey of reactions and purge processes.	The development of effective chemical processes for the control of nitrosamine contamination.	Borths et al. (2021)
2022	A review of nitrosamine impurities present in drugs	Short report the contamination events in pharmaceuticals and control measures from the global regulatory agencies such as EMA, CHMP, USFDA	Dattatraya et al. (2022)