Table 1.

Summary of ferroptosis inducers.

Ferroptosis inducers	Targets	Mechanisms	References
Erastin	SLC7A11	Inhibit System xc− and prevent cystine import	[22, 23]
RSL3	GPX4	Inhibit GPX4 covalently	[33]
FIN56	GPX4	Autophagy-mediated GPX4 degradation	[63]
Sorafenib	SLC7A11	Inhibit System xc− and prevent cystine import	[22, 23, 64]
Artesunate	FTH1,NCOA4	Promote degradation of FTH1 and NCOA4, elevate Fe2+ level, decrease GSH content	[65]
Dihydroartemisinin	GPX4, Mtor	Inhibit GPX4 directly, activate autophagy to degrade ferritin, elevate Fe2+ level	[66, 67]
Sulfasalazine	SLC7A11	Inhibit System xc− and prevent cystine import	[68]
Diallyl trisulfide	GPX4	Promote production of ROS, degradation of ferritin protein, increase the labile iron pool	[43]
Cisplatin	GPX4	GSH depletion, lipid peroxidation	[69]
Curcumin	HO-1	Accumulation of intracellular iron, increase ROS level, decrease GSH content	[70]
Flubendazole	P53	P53 binds to SLC7A11 promoter region, inhibit System xc−	[28]