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. 2023 Feb 13;30(3):321–329. doi: 10.1038/s41594-023-00922-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — Superimposition of one subunit of P116 with one subunit of P116 empty. The movement of the fingers 1-4 is indicated by dashed lines. Side view of the ribbon representation of the empty and full P116 shows that the fingers (in purple) have come closer to the core domain, massively reducing the available volume. Their new position is markedly different compared to the full P116 (shown in light blue). Finger 1 moved 8 Å sideways and towards the core, finger 2 has moved 13 Å towards the core and Finger 3 has moved 12 Å towards the core.