Skip to main content
. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: J Thorac Cardiovasc Surg. 2022 Sep 18;166(1):e5–e14. doi: 10.1016/j.jtcvs.2022.09.019

Figure 5: Among proteins involved in production of angiostatin and endostatin, cathepsin D is significantly decreased with EV therapy.

Figure 5:

Immunoblot results are shown for A) precursors to angiostatin and endostatin, B) cathepsins D and L which cleave precursors to generate angiostatin and endostatin, and C) matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinases (TIMP) 2 and 3 which regulate generation of angiostatin and endostatin. HVM, high fat diet swine that received intramyocardial extracellular vesicles (n=8), control, high fat diet swine that received saline vehicle (n=6). Upper and lower borders of box represent upper and lower quartiles, middle horizontal line represents median, upper and lower whiskers represent maximum and minimum values of non-outliers. *p<0.05 as determined by Wilcoxon rank-sum test.