Video: Clinical Implications of Reduced Anti-Angiogenic Signaling with EV Therapy in Swine with Metabolic Syndrome.

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Our group has previously shown that intramyocardial extracellular vesicle (EV) therapy improves myocardial perfusion in our swine model of chronic myocardial ischemia and metabolic syndrome, a large animal model that is relevant to patients with coronary disease and common co-morbidities. This study shows that EV therapy decreases anti-angiogenic signaling, correlating with improved perfusion, in ischemic myocardial tissue in swine with metabolic syndrome. These findings are significant as patients with coronary disease and co-morbid diabetes have increased expression of antiangiogenic signaling markers which impairs coronary collateralization and flow, and EV-mediated reduction in these markers could provide benefit.