Table 1:

Angiogenic protein expression in ischemic myocardium of EV-treated swine.

Protein	Median (IQR)	P Value
Anti-Angiogenic
Angiostatin	0.75 (0.71–0.79)	<0.001
Endostatin	0.41 (0.33–0.79)	0.043
DLL4	0.76 (0.66–1.02)	0.95
Pro-Angiogenic
Angiopoietin 1	1.31 (1.11–1.45)	0.14
β-Catenin	1.09 (0.56–1.44)	0.66
VE-Cadherin	0.67 (0.44–0.76)	0.28
Tie2	0.82 (0.59–0.99)	0.29
VEGF-A	0.62 (0.37–0.95)	0.14
FGFR1	0.91 (0.83–1.00)	1
MCP-1	1.07 (0.92–1.10)	0.85

Statistics presented as median fold change (interquartile range) of protein level in metabolic syndrome pigs treated with extracellular vesicles (HVM, n=8) compared to control (n=6). P values calculated using Wilcoxon rank sum test. DLL4, delta like ligand 4; VEGF-A, vascular endothelial growth factor A; FGFR1, fibroblast growth factor receptor 1; MCP-1, monocyte chemoattractant protein 1.