Table 2:

Protein expression related to production of angiostatin and endostatin.

Protein	Median (IQR)	P Value
Plasminogen	0.70 (0.62–0.75)	0.051
Collagen 18	0.60 (0.34–0.86)	0.49
Cathepsin D	0.64 (0.50–0.86)	0.020
Pro-cathepsin D	0.50 (0.39–0.58)	0.18
Pro-cathepsin D	0.50 (0.39–0.58)	0.18
Cathepsin L	1.11 (1.01–1.16)	0.41
Pro-cathepsin L	0.96 (0.73–1.71)	0.85
Cathepsin B	1.10 (0.95–1.13)	0.41
MMP-2	0.75 (0.71–0.90)	0.23
TIMP2	0.85 (0.81–1.30)	0.95
TIMP3	0.65 (0.46–1.38)	0.49

Statistics presented as median fold change (interquartile range) of protein level in metabolic syndrome pigs treated with extracellular vesicles (HVM, n=8) compared to control (n=6). P values calculated using Wilcoxon rank sum test. MMP-2, matrix metalloproteinase 2; TIMP2, tissue inhibitor of metalloproteinases 2, TIMP3, tissue inhibitor of metalloproteinases 3.