Table 3.
Hierarchical linear model analysis conducted with the whole sample (n = 166)
| Independent variables | GC-RS factor | HNC-RS factor | SIDA factor |
|---|---|---|---|
| b (95% CI) | b (95% CI) | b (95% CI) | |
| Gender | -0.45 (-1.18; 0.27)ns | -0.45 (-1.26; 0.37)ns | -0.67 (-1.67; 0.33)ns |
| Age | 0.0001 (-0.03; 0.03)ns | -0.01 (-0.05; 0–02)ns | 0.005 (-0.03; 0.04)ns |
| Living situation | 0.24 (-0.87; 1.35)ns | 0.20 (-1.04; 1.44)ns | 0.58 (-0.95; 2.10)ns |
| Educational level | 0.10 (-0.57; 0.77)ns | 0.46 (-0.28; 1.21)ns | 0.16 (-1.07; 0.76)ns |
| Employment status | -0.33 (-1.08; 0.4)ns | -0.28 (-1.11; 0.55)ns | 0.60 (-0.42; 1.61)ns |
| ECOG | 0.19 (-0.48; 0.87)ns | 0.32 (-0.43; 1.07)ns | 0.21 (-0.71; 1.13)ns |
| Smoker | 0.51 (-0.21; 1.23)ns | 0.34 (-0.46; 1.14)ns | 0.48 (-0.05; 1.47)ns |
| Alcohol use | -0.51 (-1.18; 0.16)ns | -0.16 (-0.91; 0–59)ns | -0.68 (-1.59; 0.24)ns |
| HPV | -0.59 (-1.32; 0.15)ns | -0.54 (-1.36; 0.28)ns | -1.59 (-2.60; -0.59)** |
| Surgery | -0.70 (-0.79; 0.65)ns | -0.49 (-1.3; 0.32)ns | -0.11 (-1–10; 0.89)ns |
| Chemotherapy | 0.34 (-0.35; 1.05)ns | 0.38 (-0.4; 1.16)ns | 0.70 (-0.26; 1.66)ns |
| Time | |||
| Linear effect | 0.33 (0.27; 0.38)*** | 0.54 (0.46; 0.62)*** | 0.37 (0.29; 0.45)*** |
| Quadratic effect | -0.02 (-0.02; -0.01)*** | -0.03 (-0.03; -0.02)*** | -0.02 (-0.02; -0.01)*** |
| Cubic effect | 0.0002 (0.0001; 0.0002)*** | 0.0003 (0.0002; 0.0003)*** | 0.0002 (0.0001; 0.0002)*** |
GC-RS, general cancer-related symptoms; HNC-RS, head and neck cancer-related symptoms; SIDA, symptom interference with daily activities; ECOG, Eastern Cooperative Oncology Group; HPV, human papilloma virus; CI, confidence interval; ns, not significant; *p < 0.05, **p < 0.01, and ***p < 0.001 (two-tailed)