Table 5.
Hierarchical linear model analysis conducted with the oropharynx HPV-positive patients (n = 66)
| Independent variables | GC-RS factor | HNC-RS factor | SIDA factor |
|---|---|---|---|
| b (95% CI) | b (95% CI) | b (95% CI) | |
| Gender | -1.14 (-1.88; -0.41)** | -0.72 (-1.49; 0.04)ns | -1.62 (-2.85; -0.39)* |
| Age at diagnosis | 0.04 (0.003; 0.08)* | 0.03 (-0.02; 0.07)ns | 0.11 (0.04; 0.18)** |
| Living situation | -0.58 (-1.42; 0.26)ns | -0.36 (-1.23; 0.51)ns | -0.74 (-2.14; 0.65)ns |
| Educational level | 1.24 (0.48; 1.99)** | 1.82 (1.05; 2.60)*** | 0.50 (-0.75; 1.75)ns |
| Employment status | 0.31 (-0.43; 1.04)ns | 0.39 (-0.37; 1.15)ns | 1.74 (0.52; 2.96)** |
| ECOG | 0.14 (-0.66; 0.94)ns | 0.91 (0.09; 1.73)* | 0.54 (-0.79; 1.88)ns |
| Smoker | 0.62 (-0.11; 1.36)ns | 0.54 (-0.22; 1.31)ns | 1.18 (-0.05; 2.41)ns |
| Alcohol use | -1.02 (-1.71; -0.33)** | -0.63 (-1.34; 0.07)ns | -1.36 (-2.51; -0.21)** |
| Surgery | 1.16 (0.11; 2.20)* | 0.66 (-0.41; 1.74)ns | 0.77 (-0.97; 2.51)ns |
| Chemotherapy | -0.17 (-1.05; 0.72)ns | -0.33 (-1.24; 0.58)ns | -0.05 (-1.52; 1.42)ns |
| Time | |||
| Linear effect | 0.39 (0.32; 0.47)*** | 0.74 (0.63; 0.84)*** | 0.43 (0.3; 0.56)*** |
| Quadratic effect | -0.02 (-0.02; -0.02)*** | -0.04 (-0.04; -0.03)*** | -0.02 (-0.03; -0.02)*** |
| Cubic effect | 0.0002 (0.0002; 0.0003)*** | 0.0004 (0.0004; 0.0005)*** | 0.0003 (0.0002; 0.0004)*** |
GC-RS, general cancer-related symptoms; HNC-RS, head and neck cancer-related symptoms; SIDA, symptom interference with daily activities; ECOG, Eastern Cooperative Oncology Group; HPV, human papilloma virus; CI, confidence interval; ns, not significant; *p < 0.05, **p < 0.01, ***p < 0.001 (two-tailed)