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. 2023 Mar 17;6:278. doi: 10.1038/s42003-023-04663-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Schematic illustration of the treatment regimen (EMPA empagliflozin). b–g Fluorescence images of a live heart from each condition (EMPA empagliflozin). Arrowheads show the sites of punctuation with a suture needle to induce ischemia. Dotted lines show the infarct regions. Warmer colors indicate higher ATP concentrations. Scale bar: 2 mm. h Time course changes in FRET/GFP ratios in the ischemic region during ischemia and reperfusion (db/db [control]: n = 6, db/db [EMPA]: n = 9; ischemia 20 min: *p = 0.001, ischemia 30 min: *p = 0.000, just after reperfusion: *p = 0.000, 15 min after reperfusion: *p = 0.001, 30 min after reperfusion: *p = 0.001).