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. 2023 Mar 17;6:278. doi: 10.1038/s42003-023-04663-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Schematic illustration of the treatment regimen (EMPA empagliflozin). b–g Fluorescence images of cardiomyocytes from each condition (EMPA empagliflozin). Warmer colors indicate higher ATP concentrations. Scale bar: 25 μm. h Time course changes in FRET/GFP ratios in the cardiomyocytes under low- and high-oxygen conditions (db/db [control]: n = 44, db/db [EMPA]: n = 40; 30 min after exposure to low-oxygen conditions: *p = 0.020, 30 min after exposure to high-oxygen conditions: **p = 0.000).