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. 2023 Mar 17;6:278. doi: 10.1038/s42003-023-04663-y

Fig. 6. Empagliflozin promotes mitochondrial activity via the NHE1 and Nav1.5 pathways.

Fig. 6

a, b Measurement of mitochondrial membrane potential using JC-1. Representative cellular images from each condition (EMPA empagliflozin). Warmer colors indicate higher mitochondrial membrane potential. Scale bar: 25 μm. c Graph of the mitochondrial membrane potential of mature cardiomyocytes with control (n = 120), empagliflozin 10 nM (n = 134). *p = 0.021. d Graph of the FRET/GFP ratio in mature cardiomyocytes isolated from 8-week-old mitoATP-Tg mice 1 h after addition of control (n = 67), 300 nM empagliflozin (n = 54), 10 μM cariporide (n = 49), cariporide and empagliflozin (n = 49), 30 μM ranolazine (n = 65), ranolazine and empagliflozin (n = 53) or 10 μM MA-5 (n = 163) (**p = 0.0012, 0.0001, 0.0000, 0.0006, 0.0011, *p = 0.046, respectively).