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. 2023 Mar 17;14:1506. doi: 10.1038/s41467-023-37208-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Atomic structures of the head (a) and base (b) modules. The color scheme is shown. The cartoon indicates the relative position of the modules in the elongated state of IFT-A. The pseudo-two-fold symmetric IFT144-IFT140 (c) and IFT122-IFT121 heterodimers (d). The central TPR junctions formed by the first four TPRs are highlighted in black dashed boxes, which are enlarged on the right. The TPRs are numbered and the inserted α-helix in each subunit is labeled with an asterisk. e A different view of the head module with IFT122 shown in the surface representation. f Close-up views of the interaction network in the base module between IFT122_WD1 and IFT139_C (1), between IFT121_WD1 and IFT43 (2), between IFT121_WD2 and IFT43 (3) and between IFT43 and IFT139-IFT121-IFT122 (4).