Table 3.
Role of microRNAs in kidney fibrosis
| microRNA | Targets | Ref. |
|---|---|---|
| Pro-fibrosis | ||
| miR-21 | TGF-β1/Smad3, Smad7, MMP9/TIMP1, PTEN/Akt, PPARα, Mpv17l, Cdc25a/Cdk6, Spry1 | 301–307 |
| miR-33 | CPT1α, CROT, HADHB | 308 |
| miR-34a | KLOTHO, Bcl-2 | 309,310 |
| miR-132 | TGF-β signaling, STAT3/ERK pathways | 311 |
| miR-150 | SOCS1 | 312 |
| miR-192 | MDM2/p53, Zeb1, ZEB2/TGF-β/CTGF, GLP-1R | 313–317 |
| miR-214 | ULK1, PTEN, E-cadherin, mt-Nd6, mt-Nd4l | 318–321 |
| miR-324 | Prep | 322 |
| miR-382 | HSPD1, PTEN/Akt, SIRP-α/STAT3, kallikrein 5, SOD-2 | 323–327 |
| miR-433 | Azin1, TGF-β/Smad3 | 328 |
| Anti-fibrosis | ||
| miR-29 | Col1-4, TPM1, HDAC4, YY1, TGF-β3, PI3K/AKT | 329–333 |
| miR-30 | SOX9, CTGF, Snail1, Snail2, Zeb2 | 334–336 |
| miR-181 | Egr1 | 337 |
| miR-200 | ZEB1, ZEB2, Snail2, KEAP1, TGF-β1 | 338–340 |
| miR-204 | PTEN11/p-STAT3, SP1 | 341,342 |
| Let-7 | Col1a2, Col4a1, TNFAIP3 | 343,344 |
AKT protein kinase B, Azin1 antizyme inhibitor 1, Cdc25a cell division cycle 25a, Cdk6 cyclin-dependent kinase 6, Col collagen, CPT1α carnitine palmitoyltransferase 1 A, CROT carnitine O-octanoyltransferase, CTGF connective tissue growth factor, Egr1 early growth response 1, ERK extracellular signal-regulated kinase, GLP-1R glucagon like peptide 1 receptor, HADHB hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta, HDAC4 histone deacetylase 4, HSPD1 heat shock protein family D (Hsp60) member 1, Keap1 kelch like ECH associated protein-1, MDM2 murine double minute 2, MMP matrix metallopeptidase, Mpv17l MPV17 mitochondrial inner membrane protein like, mt-Nd mitochondrial genes-NADH-dehydrogenase, PI3K phosphatidylinositol 3-kinase, PPARα peroxisome proliferator activated receptor alpha, Prep prolyl endopeptidase, PTEN phosphatase and tensin homolog, SIRP-α signal regulatory protein alpha, SOCS1 suppressor of cytokine signaling-1, SOD-2 superoxide dismutase 2, SOX9 SRY-box transcription factor 9, Spry1 sprout RTK signaling antagonist 1, STAT3 signal transducer and activator of transcription 3, STZ streptozotocin, TGF-β transforming growth factor beta, TIMP tissue inhibitor of matrix metalloproteinase, TNFAIP3 tumor necrosis factor alpha-induced protein 3, TPM1 tropomyosin 1, ULK1 unc-51 like autophagy activating kinase 1, YY1 Yin Yang 1, ZEB zinc finger E-box binding homeobox