Table 1.
The role of Chinese herbal compound preparations against renal injuries via regulating autophagy in DKD.
| Signaling Pathways | Chinese herbal compound preparations | Herbal composition | In Vivo/In Vitro | Model | References |
|---|---|---|---|---|---|
| PI3K/Akt/mTOR | Jiedu Tongluo Baoshen formula | Radix Astragali, Ginseng, Cornus officinalis Sieb. et Zucc, Radix et Rhizoma Rhei, Dioscorea septemloba (Diocoreacea), Euryale ferox, Pyrrosiae Folium, Radix Salvia Miltiorrhizae, Hirudo | In Vivo | rat model induced by high-fat diet and STZ | (8) |
| PI3K/Akt/mTOR | Dendrobium mixture | Dendrobium, Radix Astragali, Schisandra, Radix puerariae, Salvia miltiorrhiza, Rehmanniae and Rhizoma anemarrhenae. | In Vivo | STZ-induced rats | (9) |
| PI3K/Akt, AMPK | Yiqi Jiedu Huayu Decoction | Radix Rehmanniae, Radix puerariae, S. M. Almeida ex Sanjappa and Predeep, Coptis chinensis, Franch, and Morus alba L | In Vivo | STZ-induced rats | (10) |
| mTOR | Tongluo Digui decoction | Hirudo, Carapax et Plastrum Testudinis, Radix Rehmanniae, Radix Astragali, Radix Angelicae Sinensi, Rhizoma Alismatis, Radix et Rhizoma Rhei, and Radix Glycyrrhizae | In Vivo | STZ-induced rats | (11) |
| P62/LC3 | Keluoxin capsule | Radix Astragali, Radix Pseudostellariae, Lycium barbarum, Ligustrum lucidum, Hirudo, Radix et Rhizoma Rhei | In Vivo | STZ-induced rats | (12) |
| p-AMPK/p-ULK1, mTOR/P70S6K, SIRT1 | Tangshen Decoction | Radix Astragali, Radix Pseudostellariae, Schisandra, Radix Rehmanniae, Chinese yam, Cornus officinalis Sieb. et Zucc, Poria cocos, Paeonia suffruticosa Andr., Paeoniae Radix Rubra, Panax notoginseng | In Vivo | STZ-induced rats | (13–15) |
| AMPK/mTOR, SIRT1 | QiDiTangShen granules | Radix Astragali, Rehmanniae radix praeparata, Euryale Semen, Sophorae Tonkinensis Radix et Rhizoma, Hirudo, Radix et Rhizoma Rhei, Baihuasheshecao | In Vivo | db/db mice | (16) |
| mTORC1 | Tangshenning formula | Radix Astragali, Rhei Radix Et Rhizoma, Chuanxiong Rhizoma, and Rosae Laevigatae Fructus | In Vitro | podocyte induced by HG | (17) |
| SIRT1/NF-κB | Yishen capsules | Radix Astragali, Angelica sinensis, Euryale ferox, Alisma orientalis, and Rhodiola rosea | In Vivo/In Vitro | STZ-induced rats, mouse podocytes | (18) |
| mTOR/PINK1/Parkin | Astragalus mongholicus Bunge and Panax notoginseng (Burkill) F.H. Chen formula |
Radix Astragali, Panax notoginseng, Radix Angelicae Sinensi, Achyranthes bidentata Blume, and Ecklonia kurome Okamura |
In Vivo/In Vitro | STZ-induced rats, mouse renal mesangial cells induced by HG | (19) |
| P62/LC3 | Qidan Dihuang decoction | Radix Astragali, Radix Salvia Miltiorrhizae, Radix Rehmanniae, Chinese yam, and Liquorice | In Vivo/In Vitro | db/db mice and HG-cultured rat renal tubular epithelial cells | (20) |
| PLZF | Tangshen formula | Radix Astragali, Euonymus alatus, Radix Rehmanniae, Citrus aurantiumL., Cornus officinalis Sieb. et Zucc, Radix et Rhizoma Rhei, Panax notoginseng | In Vivo/In Vitro | db/db mice, HG-induced rat renal tubular epithelial cells | (21) |