Figure 5.

Neuroanatomical substrate of abnormal reward behaviour. Grey matter associations of the leading reward factor (factor 1) in the combined patient cohort were derived from a VBM analysis of patients’ brain MRI images (n = 96 scans; see text and Table 2 for details). Grey matter clusters were significantly associated with the factor at P < 0.05 after family-wise error correction over the whole brain. Statistical parametric maps have been rendered on coronal (left and middle) and sagittal (right) sections of the group mean template T₁-weighted MRI brain image. Coordinates in Montreal Neurological Institute space are given for each section. A bar on the right shows the corresponding voxel-wise T-values. The right hemisphere is displayed on the right in the coronal sections.