Fig. 2.

Correlation of ECM/BCM ratio and MR with ETTO in mutation carriers. Scatter plots show the correlation of Extracellular Mass (ECM)/Body Cell Mass (BCM) with the Expected Time to Onset (ETTO; a) and the correlation of the Metabolic Ratio (MR) with ETTO (b). Dotted vertical lines mark the expected time of disease onset. Negative ETTO values relate to subjects who have already passed their expected age of onset. Red dots indicate subjects who had disease onset during the observation period. p-values based on Spearman.