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. 2023 Mar 18;8:43. doi: 10.1038/s41541-023-00638-6

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

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Fig. 7 — Serum from C57BL/6 mice vaccinated (Fig. 5d) with SpFN + ALFQ or SpFN + AH (n = 5-10 for each group) was assessed for antibody avidity and antibody Fc effector functions. a Surface plasmon resonance data showing S-2P protein-specific and b RBD protein-specific antibody avidity score (Response Unit/Kd off rate) at weeks 2, 8, 16, and 21. c Antibody-dependent complement deposition (ADCD) and d Antibody-dependent cellular phagocytosis (ADCP) activities on days 7, 10 and week 6. Data were graphed as Mean ± SEM. The statistical differences between the two vaccinated groups were evaluated by Mann–Whitney U-test using the GraphPad Prism version 9 with P ≤ 0.05 considered as significant.