FIG. 3.

Map of the human wild-type p53 protein. Shown are the locations of the mtrII and ORF-1-binding domains, with the critical regions for binding indicated in black (86, 127). Also depicted are the DNA-binding domains (189), transcriptional activation and TATA-binding protein (TBP) binding domains (106), oligomerization domain (188), conserved regions (160), E6/E6-AP-binding and degradation domains (116), mdm-2- and adenovirus E1B (55-kDa)-binding domains (103), and SV40 T-antigen-binding domain (146). Adapted from reference 127 with permission of the publisher.