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Schematic showing the interactions of HCMV and HHV-6 proteins with the host tumor suppressors p53 and Rb. The HCMV mtrII and IE86 proteins and the HHV-6 ORF-1 protein bind to p53 and inhibit p53-activated transcription. HCMV IE86 also binds to Rb. Shown below p53 and Rb are the potential cellular pathways that may be deregulated by the above interactions, such as apoptosis, G1 and G2 growth arrest, and DNA repair for p53 and control of the G1-to-S-phase transition for Rb.
