Table 1.
Population characteristics evaluated according to AAD incidence
| Cases w/o AAD N = 679 |
Cases w AAD N = 79 |
p | |
|---|---|---|---|
| Age (years; IQR) | 4.9 (2.6–8.0) | 3.5 (1.7–8.9) | |
| Gendera | 0.10 | ||
| Male | 360 (53) | 36 (45) | |
| Age groupsa | 0.10 | ||
| 1–24 months | 122 (85.3) | 21 (14.7) | |
| 2–7 years | 323 (91.2) | 31 (8.8) | |
| 7–12 years | 170 (91.4) | 13 (6.9) | |
| > 12 years | 74 (85.1) | 13 (14.9) | |
| Geographic regionsa | 0.014* | ||
| Eastern Anatolia | 15 (75) | 5 (25) | |
| Southeast Anatolia | 136 (83.5) | 27 (16.5) | |
| Mediterranean Region | 30 (85.8) | 5 (14.2) | |
| Central Anatolia | 184 (90.4) | 20 (9.6) | |
| Marmara Region | 215 (93.2) | 15 (6.8) | |
| Aegean Region | 55 (93) | 4 (7) | |
| Black Sea Region | 42 (93.4) | 3 (6.6) | |
| Type of infectiona | 0.16 | ||
| Acute tonsillopharyngitis | 174 (87.4) | 24 (12.1) | |
| Lower respiratory infection | 112 (93.3) | 8 (6.7) | |
| Acute otitis media | 103 (85) | 17 (15) | |
| Acute rhinosinusitis | 105 (92.1) | 9 (7.9) | |
| Soft tissue infection | 45 (84.9) | 8 (15.1) | |
| Urinary tract infection | 45 (86.5) | 7 (13.5) | |
| Acute lymphadenitis | 78 (92.9) | 6 (7.1) | |
| Others | 17 (100) | - | |
| Treatments and dosesa | 0.48 | ||
| Aminopenicillins | |||
| Amoxicillin/clavulanic acid (usual dose)b | 250 (91.6) | 23 (8.4) | |
| Amoxicillin/clavulanic acid (high dose)c | 142 (87.7) | 20 (12.3) | |
| Amoxicillin/clavulanic acid (max dose)d | 30 (83.3) | 6 (16.7) | |
| Amoxicillin (high dose)c | 3 (100) | - | |
| Amoxicillin (usual dose)b | 8 (100) | - | |
| Ampicillin/sulbactamb | 4 (100) | - | |
| Cephalosporins | 107 (85.6) | 18 (14.4) | |
| Cefuroximee | 28 (92.9) | 2 (7.1) | |
| Cefdinirf | 43 (79.6) | 11 (20.4) | |
| Cefiximeg | 36 (87.8) | 5 (12.2) | |
| Macrolidesh | 64 (94) | 4 (6) | |
| Phenoxymethyl penicillini | 51 (89.5) | 6 (10.5) | |
| Others | 19 (92.4) | 2 (7.6) | |
aExpressed as percentages; b40-60 mg/kg/day; c80-90 mg/kg/day; d2gr/d; e10-40 mg/kg/d; f14mg/kg/d; g8 mg/kg/d; hclarithromycin: 15–30 mg/kg/d, azithromycin: 10–15 mg/kg/d; i30-80 mg/kg/d
*Overall comparison of the regions