Table 5.

Top three CpGs associated with escalation in treatment [surgery or anti-TNF therapies] in inflammatory bowel disease [IBD]

CpG probe	Gene	Chr	IBD HR training set	Function/relevance in IBD
cg26033526	TAP1	6	12.79	MHC-II encoded genes are essential in HLA class I proteins for generation of cytotoxic T-cell-mediated immune response
cg20502501	RPTOR	17	1.47	Encodes an mTOR binding protein and is part of the mammalian target of rapamycin complex 1 [mTORC1]; mTORC1 plays a role in the pathogenesis of UC39
cg06352538	TESPA1	12	1.29	Plays a role in development and maturation of T-cells and T-cell antigen receptor-mediated activation of ERK and NFAT signalling.40

HR: hazard ratio; Chr: chromosome.