Fig. 6.

Proportions of ITT patients with confirmed disability improvement who achieved NEDA, Clinical NEDA, or MRI NEDA at year 4. NEDA was defined as no relapses or 24-week CDW, no Gd+ lesions, and no new or newly enlarging T2 lesions (CDW was defined as a ≥ 1.5-point increase from a baseline EDSS score of 0.0, a ≥ 1.0-point increase from a baseline EDSS score of 1.0 to < 6.0, or a ≥ 0.5-point increase from a baseline score ≥ 6.0, confirmed 24 weeks later). Clinical NEDA was defined as no relapses or 24-week CDW. MRI NEDA was defined as no Gd+ lesions and no new or newly enlarging T2 lesions. CDW confirmed disability worsening; EDSS Expanded Disability Status Scale; Gd+ gadolinium-enhancing; ITT Intent-to-treat; MRI magnetic resonance imaging; NEDA No Evidence of Disease Activity