Table 4.

Baseline characteristics of ITT patients with baseline EDSS score ≥ 2.0 and those with baseline EDSS score ≥ 2.0 who experienced CDI

Characteristic	Patients with baseline EDSS score ≥ 2.0 (n = 133)	Patients with baseline EDSS score ≥ 2.0 who achieved CDI (n = 43)
Age, mean (SD), y	33.9 (8.6)	32.9 (8.8)
Female, n (%)	91 (68.4)	26 (60.5)
Number of relapses in the past 12 months, mean (SD)	1.5 (0.9)	1.6 (1.0)
EDSS score, mean (SD)	2.8 (0.8)	2.9 (0.9)
MS duration, mean (SD), y	1.6 (0.8)	1.6 (0.9)
T2 lesion volume, mean (SD), cc	8.4 (10.9)	7.1 (8.0)
Number of Gd+ lesions, mean (SD)	2.6 (7.5)b	4.0 (12.0)b
Prior MS treatment, n (%)	68 (51.1)	18 (41.9)
SDMT score, mean (SD)	49.2 (14.9)	50.6 (13.2)
MSIS-29, mean (SD)c
Physical score	47.8 (20.0)	42.0 (17.7)
Psychological score	23.8 (9.6)	22.0 (9.3)
WPAI, mean (SD)
Work missed/week due to MS, hd	8.0 (15.1)e	9.7 (14.4)e
Regular activities affected by MSf	4.3 (2.9)g	3.8 (3.2)g

CDI confirmed disability improvement, EDSS Expanded Disability Status Scale, Gd+ gadolinium- enhancing, ITT intent-to-treat, MS multiple sclerosis, MSIS-29 Multiple Sclerosis Impact Scale, SD standard deviation, SDMT Symbol Digit Modalities Test, WPAI Work Productivity and Activity Impairment Questionnaire

^aP values for continuous variables are based on t-test; P values for sex and prior disease-modifying therapy use are based on chi-squared test

^bData were missing for 14 patients (four patients with CDI)

^cData were missing for three patients (one patient with CDI)

^dQuestion posed: “How many hours did you miss from work because of problems associated with MS?”

^eData were missing for 56 patients (13 patients with CDI)

^fQuestion posed: “How much did MS affect your ability to do your regular daily activities other than work at a job? Scale is from 0 (no effect) to 10 (completely prevented daily activities)”

^gData were missing for two patients (one patient with CDI)