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. 2023 Mar 18;12(1):16. doi: 10.1038/s41389-023-00460-8

Fig. 2. FASN deregulates cell metabolism.

Fig. 2

Many enzymes are upregulated in cancer cells including the lipogenic enzymes ACLY, ACC, and FASN. Their overexpression leads to an increased lipid synthesis sustained by the Warburg effect. In addition FASN promotes mTOR activation resulting in an increased protein synthesis. FASN also favors the activity of the PPP (pentose-phosphate pathway) enzyme PGDH by increasing the pool of NADP+, a co-substrate of the latter. PPP upregulation concomitantly increases DNA/RNA synthesis. The dotted arrows represent an indirect effect. PGDH, 6-phosphogluconate dehydrogenase; AcCoA, acetyl-CoA; MalCoA, malonyl-CoA; TCA, tricarboxylic acid cycle; OAA, oxaloacetic acid; ACLY, ATP citrate lyase; ACC, acetyl-CoA carboxylase; PPP, pentose-phosphate pathway; mTOR, mammalian/mechanistic target of rapamycin; FASN, fatty acid synthase.