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. 2023 Mar 18;12(1):16. doi: 10.1038/s41389-023-00460-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — FASN is phosphorylated by HER2 increasing its activity and being responsible for an activation of MMP-9 that degrades the extracellular matrix (ECM). FASN exerts a positive feedback loop by allowing HER2 localization into lipid rafts. Through a respective reduction and increase of E-cadherin and vimentin expression, FASN promotes EMT reinforced by the proper localization of the c-Met receptor into lipid rafts. FASN interacts with Src and caveolin-1. FASN indirectly participates in caveolin-1 palmitoylation which in turn promotes Src and Akt activity leading to cell migration. The dotted arrows represent an indirect effect.