Table 2.
DLB core features in men and women
| Reference | Cohort (Total N, % men) |
RBD (N, %) | p-value | Parkinsonism (N, %) |
p-value | Visual hallucinations (N, %) |
p-value | Fluctuations (N, %) |
p-value | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Men | Women | Men | Women | Men | Women | Men | Women | ||||||
| Choudhury et al., 2021 [15] | 488 (76) | 311 (84) | 61 (52) | <0.001 | 335 (91) | 98 (83) | 0.025 | 244 (66) | 97 (82) | 0.001 | 286 (77) | 87 (74) | 0.43 |
| Bayram et al., 2021 a [14] | 110 (50) | 28 (51) | 16 (29) | >0.29 | 47 (86) | 42 (76) | >0.29 | 35 (64) | 22 (40) | <0.05 | 31 (56) | 27 (49) | >0.29 |
| Bayram et al., 2022 b [20] | 691 (68) | 165 (45.8) | 35 (20.8) | <0.001 | 278 (71.5) | 90 (50.6) | <0.001 | 255 (54.4) | 85 (38.3) | <0.001 | 201 (55.2) | 70 (40.9) | <0.005 |
| Utsumi et al., 2020 [17] | 234 (43) | 76 (76) | 66 (50) | <0.001 | 60 (59) | 59 (44) | 0.027 | 77 (76) | 109 (82) | NS | 54 (54) | 78 (58) | NS |
| Van de Beek et al., 2020 [18] | 223 (83) | 99 (73) | 11 (55) | 0.17 | 130 (73) | 23 (62) | 0.28 | 69 (38) | 23 (59) | 0.02 | 119 (84) | 29 (94) | 0.26 |
| Ferreira et al., 2020 [54] | 416 (69) | 210 (73) | 79 (61) | 0.48 | 253 (88) | 107 (83) | 0.023 | 152 (53) | 93 (72) | 0.04 | 230 (80) | 112 (87) | 0.53 |
| Chiu et al., 2018 c [55] | 152 (57) | N/A | N/A | N/A | N/A | N/A | N/A | 39 (45) | 39 (60) | 0.028 | N/A | N/A | N/A |
DLB=dementia with Lewy bodies; NS=not significant (p-value not provided)
a
Showing data from the study’s matched subsamples (by age, education, tau burden; n=55 women, n=55 men); in the overall cohort, additional statistically significant sex differences were found for RBD (men 56% vs. women 29%, p<0,01), and parkinsonism (men 92% vs. women 76%, p<0.01) (Bayram et al., 2021).
b
Unlike their prior study [14] that excluded individuals with Braak tau staging > III, this study [20] included pathologically-confirmed DLB sample with all Braak tau stages 0-VI.
c
As this study focused on sex differences in DLB in visual hallucinations only, there are no available data on sex differences in other DLB core features.