Table 2A.
Association between ApoA1 levels and adverse outcomes. Overall cohort
| Outcome | Model | 0.42–1.22 g/L (95% CI) | 1.23–1.32 g/L (95% CI) | 1.33–1.39 g/L (95% CI) | 1.40–1.45 g/L (95% CI) | 1.46–1.52 g/L (95% CI) | 1.53–1.59 g/L (95% CI) | 1.60–1.66 g/L (95% CI) | 1.67–1.75 g/L (reference) | 1.76–1.91 g/L (95% CI) | 1.91–2.50 g/L (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| All-cause mortality | Unadjusted | 1.65 (1.56–1.75); P < 0.0001 | 1.32 (1.25–1.40); P < 0.0001 | 1.17 (1.10–1.24); P < 0.0001 | 1.08 (1.02–1.15); P = 0.0074 | 1.03 (0.97–1.10); P = 0.2887 | 1.07 (1.01–1.13); P = 0.0341 | 1.02 (0.96–1.08); P = 0.6025 | 1.00 | 1.03 (0.97–1.10); P = 0.3085 | 1.09 (1.03–1.15); P = 0.0053 |
| Adjusteda | 1.31 (1.24–1.39); P < 0.0001 | 1.13 (1.06–1.20); P < 0.0001 | 1.03 (0.97–1.09); P = 0.3563 | 1.00 (0.94–1.06); P = 0.9007 | 0.97 (0.91–1.03); P = 0.2642 | 1.02 (0.96–1.08); P = 0.4989 | 0.99 (0.93–1.05); P = 0.7545 | 1.00 | 1.06 (1.00–1.13); P = 0.0533 | 1.14 (1.07–1.21); P < 0.0001 | |
| PGS Adjustedb | 1.29 (1.22–1.37); P < 0.0001 | 1.12 (1.05–1.18); P = 0.0004 | 1.02 (0.96–1.08); P = 0.5495 | 0.99 (0.93–1.05); P = 0.7316 | 0.96 (0.91–1.03); P = 0.2377 | 1.02 (0.96–1.08); P = 0.6102 | 0.99 (0.93–1.05); P = 0.6958 | 1.00 | 1.07 (1.01–1.14); P = 0.032 | 1.15 (1.08–1.22); P < 0.0001 | |
| CV mortality | Unadjusted | 2.08 (1.87–2.31); P < 0.0001 | 1.52 (1.36–1.69); P < 0.0001 | 1.32 (1.18–1.47); P < 0.0001 | 1.24 (1.10–1.39) P = 0.0002 | 1.11 (0.99–1.25) P = 0.0788 | 1.22 (1.08–1.36); P = 0.0008 | 1.05 (0.94–1.18); P = 0.3975 | 1.00 | 1.11 (0.99–1.25); P = 0.0811 | 1.09 (0.96–1.23); P = 0.1757 |
| Adjusteda | 1.35 (1.20–1.51); P < 0.0001 | 1.12 (1.00–1.26); P = 0.0456 | 1.03 (0.91–1.15); P = 0.6622 | 1.03 (0.92–1.16); P = 0.5946 | 0.95 (0.85–1.07); P = 0.4179 | 1.10 (0.98–1.23); P = 0.1143 | 0.99 (0.88–1.12); P = 0.8676 | 1.00 | 1.18 (1.04–1.33); P = 0.0076 | 1.21 (1.07–1.37); P = 0.0022 | |
| PGS Adjustedb | 1.30 (1.16–1.46); P < 0.0001 | 1.09 (0.97–1.23); P = 0.1396 | 1.00 (0.89–1.13); P = 0.9617 | 1.01 (0.90–1.14); P = 0.82 | 0.94 (0.83–1.06); P = 0.2962 | 1.08 (0.96–1.22); P = 0.1868 | 0.99 (0.88–1.11); P = 0.8407 | 1.00 | 1.19 (1.05–1.34); P = 0.0056 | 1.23 (1.09–1.39); P = 0.0011 |
Cox proportional hazards models were used for all-cause death; Fine and Gray’s sub-distribution hazard models were used for cardiovascular death, treating the non-cardiovascular deaths as competing risks.
a
Adjusted for age, sex, race, body mass index, hypertension, diabetes, current/former smoking, frequency of alcohol use (defined as graded variable on scale of 0–5), triglycerides, LDL-C, eGFR.
b
Adjusted for age, sex, race, body mass index, hypertension, diabetes, current/former smoking, frequency of alcohol use (defined as graded variable on scale of 0–5), triglycerides, LDL-C, eGFR, PGS and top 10 principal components.
Statistical significance defined at P<0.05 (bold font).