Table 2B.
Association between ApoA1 levels and adverse outcomes. Male only cohort.
| Outcome | Model | 0.42–1.17 g/L (95% CI) | 1.18–1.24 g/L (95% CI) | 1.25–1.30 g/L (95% CI) | 1.31–1.36 g/L (95% CI) | 1.37–1.41 g/L (95% CI) | 1.42–1.47 g/L (95% CI) | 1.48–1.53 g/L (reference) | 1.54–1.61 g/L (95% CI) | 1.62–1.73 g/L (95% CI) | 1.74–2.50 g/L (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| All-cause mortality | Unadjusted | 1.68 (1.56–1.80); P < 0.0001 | 1.36 (1.26–1.47); P < 0.0001 | 1.18 (1.09–1.27); P < 0.0001 | 1.10 (1.02–1.19); P = 0.0135 | 1.07 (0.99–1.15); P = 0.1004 | 1.02 (0.94–1.10); P = 0.6797 | 1.00 | 0.99 (0.92–1.07); P = 0.815 | 1.01 (0.94–1.10); P = 0.7406 | 1.23 (1.14–1.32); P < 0.0001 |
| Adjusteda | 1.40 (1.30–1.52); P < 0.0001 | 1.22 (1.13–1.32); P < 0.0001 | 1.09 (1.01–1.18); P = 0.0357 | 1.04 (0.96–1.13); P = 0.2916 | 1.03 (0.95–1.12); P = 0.34204 | 0.99 (0.92–1.08); P = 0.8908 | 1.00 | 1.01 (0.93–1.09); P = 0.9058 | 1.04 (0.96–1.12); P = 0.355 | 1.27 (1.18–1.37); P < 0.0001 | |
| PGS Adjustedb | 1.38 (1.28–1.49); P < 0.0001 | 1.21 (1.12–1.30); P < 0.0001 | 1.08 (1.00–1.17); P = 0.0623 | 1.03 (0.95–1.12); P = 0.4331 | 1.03 (0.95–1.11); P = 0.5184 | 1.00 (0.92–1.08); P = 0.8944 | 1.00 | 1.01 (0.93–1.09); P = 0.8068 | 1.04 (0.96–1.13); P = 0.2977 | 1.29 (1.19–1.39); P < 0.0001 | |
| CV mortality | Unadjusted | 2.04 (1.80–2.31); P < 0.0001 | 1.59 (1.39–1.81); P < 0.0001 | 1.34 (1.17–1.53); P < 0.0001 | 1.16 (1.01–1.33) P = 0.037 | 1.24 (1.08–1.42) P = 0.0023 | 1.16 (1.01–1.33); P = 0.0363 | 1.00 | 1.09 (0.95–1.25); P = 0.2343 | 0.97 (0.84–1.12); P = 0.7025 | 1.28 (1.12–1.46) P = 0.0002 |
| Adjusteda | 1.52 (1.33–1.74); P < 0.0001 | 1.29 (1.12–1.48); P < 0.0001 | 1.17 (1.02–1.35); P = 0.0279 | 1.05 (0.91–1.21); P = 0.5369 | 1.15 (1.00–1.33); P = 0.048 | 1.11 (0.96–1.28); P = 0.1504 | 1.00 | 1.13 (0.98–1.31); P = 0.0831 | 1.05 (0.90–1.21); P = 0.5559 | 1.44 (1.26–1.65); P < 0.0001 | |
| PGS Adjustedb | 1.50 (1.30–1.72); P < 0.0001 | 1.27 (1.11–1.46); P = 0.0007 | 1.16 (1.01–1.34); P = 0.0421 | 1.04 (0.90–1.20) P = 0.6298 | 1.15 (1.00–1.33) P = 0.0501 | 1.12 (0.97–1.29); P = 0.1283 | 1.00 | 1.15 (1.00–1.33); P = 0.059 | 1.07 (0.92–1.24); P = 0.3895 | 1.48 (1.29–1.70) P < 0.0001 |
Cox proportional hazards models were used for all-cause death; Fine and Gray’s sub-distribution hazard models were used for cardiovascular death, treating the non-cardiovascular deaths as competing risks.
a
Adjusted for age, race, body mass index, hypertension, diabetes, current/former smoking, frequency of alcohol use (defined as graded variable on scale of 0–5), triglycerides, LDL-C, eGFR.
b
Adjusted for age, race, body mass index, hypertension, diabetes, current/former smoking, frequency of alcohol use (defined as graded variable on scale of 0–5), triglycerides, LDL-C, eGFR, PGS and top 10 principal components.
Statistical significance defined at P<0.05 (bold font).